The use of anti-hypertensive drugs at bedtime or night has been a rare phenomena except when ACE inhibitors are introduced as an add-on therapy for the first week on patients,especially when they are on diuretics like furosemide, which is suspended for some few days.The purpose is to avoid rapid fall in blood pressure which can lead to collapse. It is exciting to know that some drugs have what we called chronotherapeutic benefits related to circadian rhythms. One such drug is doxazosin. Recommending the intake of this drug at night has always offered good blood pressure control. Whenever I carry MUR with my patients and realize that their blood pressure is not under control. I have always advise them to switch doxazosin at night and within three weeks of monitoring the blood pressure, it is amazing to see that the pressure is within sensible range
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