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CPD Toolkit: basic pharmacokinetics part 2 - the metabolism and excretion of medicines

CPD Toolkit: basic pharmacokinetics part 2 - the metabolism and excretion of medicines

This module focuses on basic pharmacokinetics and was created originally as Update Module 1497 and was first published as part of the Update 2009 course in October 2009. This course has been reviewed and revised by the author to ensure it is up to date. In the second of two articles Dr Russell Greene looks at the metabolism and excretion of medicines 60-second summary How are most drugs metabolised?  Direct modification (oxidation, hydrolysis or decarboxylation) facilitated by CYP P450 enzymes makes the drug more hydrophilic so it can be excreted by the kidney. Addition of water-soluble side chains (conjugation) further helps renal or biliary elimination. Age, genetics and liver disease can affect these processes, although liver disease has a less predictable effect on metabolism than kidney disease has on

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